Safeguard your skin from the inside out Life Extension offers an oral supplement to help protect against harmful solar radiation. Shade Factor combines three unique ingredients to support the body’s natural immune response to UV exposure: Nicotinamide, Polypodium leucotomos extract, and Red Orange Complex®. These nutrients can complement topical sunscreens – which are useful and effective at skin cancer prevention – by protecting even hard-to-reach areas of one’s skin. And unlike lotions and sprays, Shade Factor won't wash off when you swim or sweat. Nicotinamide & fern extract promote healthy DNA function after UV exposure Our bodies have multiple systems that can repair damage to our genetic material inflicted by ultraviolet radiation. Nicotinamide plays a significant role in boosting the production of cellular energy that these systems require to function properly. In addition, nicotinamide has been shown to support the natural immune response needed to protect against the age-related effects of ultraviolet exposure. During a decade of research, an extract of the fern Polypodium leucotomos has been demonstrated to inhibit cellular changes in the skin that can lead to premature aging from outdoor activity Red Orange Complex® supports natural photo-protection Shade Factor also contains Red Orange Complex™, an extract obtained from three red orange varieties. Active compounds, including flavanones, anthocyanins and hydroxycinnamic acids (as well as ascorbic acid) work together to support the body's natural photo-protection against the age-related effects of ultraviolet radiation.